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SpyMe Tools is very useful in detecting Registry and Disk changes. If any application installs spyware, adware, dlls, programs, files, or any other type of file, picture, or program, etc. or changes the Registry's content, you will be able to see exactly where the modification occurred so you can take measures. It seems like more and more programs are attempting to install spyware, advertisements, or other garbage without your knowledge, but with this software you will know everything that is added or removed.
http://www.lcibrossolutions.com/spyme_tools.htm